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Μετά τη λήψη μιας δόσης Valtrex 1 δ σιμετιδίνη και προβενεσίδη, ότι σωληναριακή έκκριση μπλοκ, ακυκλοβίρη αύξησε την AUC και τη μείωση της νεφρικής κάθαρσης της.